Oral Bioavailability in Special Populations

The extent of absorption following oral administration of drugs may vary among patients. There are several factors that can contribute to this variability including age, gender, disease state, genetic variability, and body weight. The impact of these factors on the extent of absorption is not the same. As body exposure to the administered dose will potentially affect the therapeutic effect of the drug, it is important to understand the impact of each of these factors on the extent of absorption to be able to adjust the dosing regimen and achieve a therapeutic outcome.